Comment on “ApoE-Directed Therapeutics Rapidly Clear b-Amyloid and Reverse Deficits in AD Mouse Models”
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چکیده
Cramer et al. (Reports, 23 March 2012, p. 1503; published online 9 February 2012) reported that bexarotene rapidly reduces b-amyloid (Ab) levels and plaque burden in two mouse models of Ab deposition in Alzheimer’s disease (AD). We now report that, although bexarotene reduces soluble Ab40 levels in one of the mouse models, the drug has no impact on plaque burden in three strains that exhibit Ab amyloidosis.
منابع مشابه
Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models".
Cramer et al. (Reports, 23 March 2012, p. 1503; published online 9 February 2012) demonstrated in a mouse model for Alzheimer's disease (AD) that treatment of APP/PS1ΔE9 mice with bexarotene decreased Aβ pathology and ameliorated memory deficits. We confirm the reversal of memory deficits in APP/PS1ΔE9 mice expressing human APOE3 or APOE4 to the levels of their nontransgenic controls and the si...
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تاریخ انتشار 2013